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In pregnancy, COVID-19 mRNA vaccines are safe


COVID-19 mRNA vaccines have a good safety profile in pregnancy, according to a study published online Aug. 11 in The Lancet Infectious Diseases.

Manish Sadarangani, D.Phil., from the BC Children’s Hospital Research Institute in Vancouver, British Columbia, Canada, and colleagues examined the frequency and nature of significant health events among pregnant women after COVID-19 mRNA vaccination in seven Canadian provinces and territories. Data were collected by self-reported survey after both vaccine doses for pregnant and nonpregnant women aged 15 to 49 years.

Overall, 5,597 pregnant participants had received dose 1 and 3,108 received dose 2, while 174,765 and 91,131 nonpregnant participants had received doses 1 and 2, respectively. The researchers found that among vaccinated pregnant women, 4.0 and 7.3 percent reported a significant health event after dose 1 and dose 2, respectively, compared with 3.2 percent of pregnant unvaccinated women. The odds of a significant health event within seven days after vaccine dose 2 of mRNA-1273 were increased compared with pregnant unvaccinated controls in the previous seven days (adjusted odds ratio, 4.4); no increase was seen after dose 1 of mRNA-1273 or after BNT162b2. Compared with nonpregnant vaccinated women, pregnant vaccinated women had reduced odds of a significant health event after dose 1 and 2 of any mRNA vaccination (adjusted odds ratios, 0.63 and 0.62, respectively).

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