In a major breakthrough, an Israeli laboratory claimed to have grown the first synthetic mouse embryo made by a technique that used stem cells instead of egg and sperm methods. The study, titled “Postgastrulation synthetic embryos generated ex utero from mouse naïve ESCs,” was published Monday in the journal Cell. This development represents stem cells producing advanced embryos, citing cell biologist Professor Jacob Hanna of the Weizmann Institute of Science.
Hannah, along with team members including Jewish, Arab-Israeli and Palestinian graduate students, said previous attempts yielded only blastocysts, which form during early mammalian development. A blastocyst has only a small fraction of the millions of cells in his embryo. “It’s remarkable,” he commented. “Although he had no sperm, no eggs, and no uterus, he was able to form an embryo from stem cells alone, up to eight days, a third of his gestation period in heart-beating mice. ”
Hannah said the research could one day be used to grow artificial human embryo-like structures to create cells for future medical solutions. patients will one day be able to donate their skin and blood cells for the growth of artificial embryo-like structures. PhD Senior Gynecologist, Obstetrician and In Vitro Fertilization Specialist Shivani Sachidev Ghoul : It completely throws away the notion that an egg’s sperm is needed to make an embryo. ” Gour explained that synthetic embryos meant they were made from mouse stem cells rather than eggs or sperm cells. “It’s really a milestone. The embryos created had a beating heart, a brain-like, gut-like structure. It stretched for 8.5 days. The normal gestation period for mouse embryos is 20 days.”
But when it hits 8.5 days, it’s like science fiction coming to life,” she added. Gour noted that this synthetic embryo has great potential for her two groups. One group is people in need of organ donors, and research may extend to human organ development. “The second is in vitro fertilization or invitational insemination. Many IVF cycles fail at this stage after the embryo is placed in the uterus.
This study helps us understand some of the mechanisms by which in vitro fertilization fails. , which can help improve the success rate. Care must be taken as these synthetic embryos still have a long way to go as they were unable to grow in the uterus after implantation.
- Israeli researchers make a breakthrough by creating a synthetic mouse embryo in a lab
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